explain the mechanism of blood clotting?
Blood clotting helps for the excessive loss of blood from an injury caused to the body. It is initiated by platelets. Thromboplastin is a lipoprotein plays a major role in blood clotting.
Clot formation occurs in three steps.
- Thromboplastin helps in the formation of prothrombinase enzyme. This enzyme inactivates heparin and it also converts the inactive prothrombin into active thrombin. Calcium ions helps for these changes.
- Thrombin acts as a proteolytic enzyme to separate two peptides from the soluble fibrinogen molecule to form insoluble fibrin.
- The fibrin polymerizes to form long, sticky fibres. The fibrin threads form a fine network over the wound and tap blood cells to form a crust – the CLOT.
Clot is formed in about 2 – 8 minutes and seals the wound and stop bleeding.