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Phosphorylation of the regulatory light chain of myosin by the Ca2+/calmodulin -dependent myosin light chain kinase plays an important role in smooth muscle contraction. contraction of smooth muscle through increases in myosin ATPase activity and crossbridge cycling. Calcium binds and activates myosin light chain kinase (MLCK), which then phosphorylates myosin light chainPhosphorylation of  increases myosin adenosine triphosphatase (ATPase) activity, which leads to cross-bridge cycling and contraction. 
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