Explain this urea cycle briefly

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Please find below the solution to the asked query

Urea cycle (Ornithine cycle) is the biochemical cycle that involves conversion of harmful and toxic ammonia (NH3)​ into less toxic urea ((NH2)CO)​. ​It occurs mainly in the liver of ureotelic organisms.  
 It consist of five reactions. Among them two reactions take place in the mitochondria and remaining three in cytosol.
The overall reaction is as under:
2NH3 + CO2 + 3ATP + H2O → urea + 2ADP + 4Pi + 1 AMP 


This cycle uses three ATPs. These three ATPs are used during following reactions:
  1. NH3  + CO2  + 2ATP    →  Carbamoyl phosphate + 2ADP + Pi
  2. Citrulline + Aspartate + ATP   →   Argininosuccinate + AMP + 2Pi

Hope this information will clear your doubts about the number of ATPs used in urea cycle.
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