How tge germs were used as the powerfull weapon for the colonisation of america

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The Spanish and Portuguese  conquest and colonisation of America was decisively under way by the mid-sixteenth century. European conquest was not only a result of superior firepower. Infact, the most powerful weapon of the Spanish conquerors were not only conventional military weapon at all, It was germs such as smallpox, that they carried on their person. Because of their long isolation, America's inhabitants had no immunity against these diseases that came from Europe. Smallpox, once introduced, it spread deep into the continent. It killed whole communities, paving the way for conquest and colonisation.