name and number the different clotting factors involved in clotting of blood?

There are 13 blood clotting proteins (coagulation factor) found in the blood. They are designated by Roman Numerals I through XIII. When a blood vessel is damaged, these clotting factors are switched on in a certain order (Blood Clotting Cascade) [link to coagulation page] and work to form a clot. Specifically, these 13 factors normally combine to a clot.

If one factor is missing or present at low levels, this causes hemophilia and other blood clotting problems and a proper clot will not form.

The two most common factor deficiencies are: factor 8 (or factor VIII) deficiency and factor 9 (or factor IX) deficiency. The most common, affecting 80% of the hemophilia population - those with hemophilia A - is factor VIII. When these blood clotting proteins aren't present is not easily stopped.

This factor is so important to the treatment of hemophilia, that instead of saying they have "hemophilia A or B," most people say they are "Factor VIII" or "Factor IX" to identify their condition.





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The information on 21 proteins involved in blood coagulation pathway is as follows: Fibrinogen (factor I) consists of three polypeptide chains - alpha, beta and gamma. It is converted to fibrin (factor Ia) by thrombin (factor IIa). Fibrin forms a mesh around the wound ultimately leading to blood clot.
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